Cutting Edge Cannabis Science

The bioavailability of an active ingredient given through the oral administration is highly dependent on the solubilization of the active. Poorly water soluble actives have extremely low bioavailability and hence require higher dosing which can lead to side effects. 


CBD solubilized with Oneness OS shows a 10x increase in solubilization in water as compared to CBD dispersed in oil. CBD solubilized with Oneness OS shows a 3x fold increase compared to the existing market leading water soluble CBD. 


Additionally, CBD solubilized with Oneness OS also shows a rapid onset of action as 100% of the CBD is solubilized after just 5 minutes, whereas after 30 minutes, only 32% of the leading market competitor was solubzilied.


Additionally, Oneness’s CBD was solubilized directly from organic full-spectrum hemp extract, whereas the competitor solubilized CBD from hemp oil distillate which filters out much of the original organic plant matter.

FDA Pharmaceutical-Grade Drug Release Study (Solubilization in Water)
Gut Solubilization Study

Bile salts are the natural solubilizers in the digestive system secreted when the body detects lipids. The data below show the solubilization of a lipid based active ingredient in the presence of sodium taurocholate, a major component of bile with in the gut. The study compares the active ingredient alone vs the active ingredient solubilized via Oneness Technology. 

The greater an active ingredient is solubilized, the more it permeates the gut membrane resulting in increased bio-availability.

Oneness’s solubilization technology shows a 10x increase in the solubilization of the active ingredient in bile salts indicating drastically improve gut membrane permeation into of the active into the bloodstream. 

Gut Lining Permeation Study

The permeation of the active ingredients from the gut into the body can be through 2 pathways: (1) in between the cells ‘para-cellular’ or (2) through the cells ‘trans-cellular’.


A radiolabeled propranolol (called trans-cellular tracer) was used to measure %active permeated into the body by trans-cellular pathway (through the gut lining). Radiolabeled mannitol (called para-cellular tracer) measured %active permeated into the body by paracellular pathway.


Oneness Tech shows a increase in permeation of active ingredients through the gut lining through the dual pathways, that is, in between the cells and through the cells.  

Trans Epithelial Electric Resistance (TEER)

Trans Epithelial Electrical Resistance (TEER) value reflects physical structures and properties of filter-grown epithelial cultures, in our case the intestinal epithelial cells. TEER measurement assesses the permeability of tight junctions between the cell lines or the membrane perturbation by toxicants on intestinal and kidney epithelial cell lines.


A TEER value of greater than 60 ohms represents a healthy gut lining. However, the higher the TEER value lower the permeability of substances through the membrane into the body. 


Oneness shows a decrease in TEER value indicating improvement in the permeability of the membrane. However, TEER value remains above 60 ohms which indicates a healthy gut line.

More coming soon...

Botanicals such as hemp and cannabis have the potential to radically improve human wellbeing across a vareity of dimensions. However, like all botanicals (and most supplements and pharmaceutical molecules), hemp and cannabis are hydrophoic, that is, poorly soluble in water. This leads to two primary problems

   1) Poor absorption (low bioavailability) - which inhibits both safety and efficacy

   2) Limited product application possibilities

The human body is mostly composed of water and the human bloodstream which carries nutrients throughout the body is over 90% water by weight. Therefore, the better a nutrient is solubilized in water, the more effectively it can be used and absorbed in the human system.  

Oneness OS is a phase-shift drug delivery technology that radically enhances the solubility and bioavailablity of active ingredients.

Scientific Foundation

Energy and vibration is the basis of all forms in the universe. Einstein’s E = mc^2 means everything we experience is energy vibrating in different manifestations. On this planet, water and carbon are the fundamental physical ingredients for all life, including plants and human beings. By aligning these elements of hydrogen, oxygen, and carbon in a certain geometry and by applying certain dimensions of energy and vibration to the system, a powerful key can be created that unlocks deeper connections between plants and humans. That master key is called Oneness OS, a phase-shift delivery platform that drastically enhances the efficacy of botanicals by radically enhancing solubility and bioavailability. 

Phase-Shift Technology

Oneness OS is a new dimension of therapeutic delivery technology known as a phase-shift delivery system. A phase-shift delivery platform distinguishes itself from all other drug delivery systems by its

    1) Adaptability - the ability to work with a wide variety of active ingredients from organic botanical

        extracts to pharmaceutical drug molecules

    2) Ease of Implementation - the ability to effortlessly integrate into existing manufacturing


    3) Quality - the ability to create 100% solubilized highly shelf-stable solutions

Oneness OS is the only technology in the world that qualifies across all of the metrics as a phase-shift technology. The platform is able to dynamically interface with the actives individually to solubilize them most effectively. This is most vital when working with a complex plant such as cannabis that has over 400 unique compounds all with varying molecular structures, densities, surface chemistries, solubility capacities, and other properties. Whether the components are in a solid phase, oil phase, or liquid phase, Oneness OS can simultaneously shift them into an integrated, uniform, and highly shelf-stable water soluble solution. 

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